Electrophysiologic effects of procaine amide in patients with intraventricular conduction delay.
نویسندگان
چکیده
was achieved at the end of infusion. Mean control A-V nodal conduction times (A-H: 99.5 -+34 msec) and A-H at peak PA levels (90 + 15.3) did not differ significantly. However, the mean infranodal conduction time (H-Q) at peak PA (68.1 + 14.8 msec) was significantly higher than control measurements (57.6 13 msec) (P < 0.001), with a mean percent increase of 18% (11 msec), and maximal prolongation of H-Q occurred at peak PA blood levels. There was no statistically significant correlation between maximum absolute or percent change in H-Q and control H-Q, control QRS duration, or peak PA levels. One patient with sinus bradyeardia had further decreases in rate and a junctional rhythm after PA. Intravenous administration of PA appears safe and effective for patients with IVCD in terms of arrhythmia control and absence of high degree A-V block, ventricular ectopic beats, or standstill, but caution should be used in treating patients with sinus bradyeardia.
منابع مشابه
Transient ventricular fibrillation. IV. The effects of procaine amide on patients with transient ventricular fibrillation during established auriculoventricular dissociation.
Procaine amide was given intravenously to three patients with transient ventricular fibrillation during established auriculoventricular dissociation at a time when they were free from symptoms as well as during the attacks. It was determined that this drug has a transitory slowing effect upon the auricles. It depresses rhythmicity in the auriculoventricular node, prolongs the refractory period ...
متن کاملFurther observations on the electrophysiologic effects of oral amiodarone therapy.
A case is presented of a reversible intra-Hisian block occurring under amiodarone treatment for atrial tachycardia in a patient without clear intraventricular conduction abnormalities. His bundle recordings showed an atrial tachycardia with intermittent exit block and greatly prolonged BH and HV intervals (40 and 100 msec, respectively). Thirty days after amiodarone discontinuation, His bundle ...
متن کاملProcaine Amide Against Re-Entrant Ventricular Arrhythmias Lengthening RNV Intervals of Coupled Ventricular Premature Depolarizations
Nine patients with coupled ventricular premature depolarizations (VPDs) were treated with intravenous procaine amide to abolish the arrhythmia. The effect of procaine amide on the electrocardiogram was carefully observed. Seven patients were treated with intermittent intravenous therapy-10( mg of procaine amide was injected every five minutes-and two were treated by constant intravenous infusio...
متن کاملElectrophysiologic Delineation of the Intraventricular His Bundle in Two Patients with Endocardial
Two patients who had an endocardial cushion type of ventricular septal defect underwent electrophysiologic studies for detection of specialized conduction tissue during operative repair. In one patient, with an inferior leftward frontal plane QRS axis on the ECG, we recorded an intraventricular His bundle electrogram anterior and superior to the ventricular septal defect. In the other patient, ...
متن کاملElectrophysiologic Delineation of the Intraventricular
Two patients who had an endocardial cushion type of ventricular septal defect underwent electrophysiologic studies for detection of specialized conduction tissue during operative repair. In one patient, with an inferior leftward frontal plane QRS axis on the ECG, we recorded an intraventricular His bundle electrogram anterior and superior to the ventricular septal defect. In the other patient, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Circulation
دوره 49 3 شماره
صفحات -
تاریخ انتشار 1974